Some other molecules, most of which are also expressed by cancer stem cells, have been found to be associated with vasculogenic tumor cells, including VE-cadherin, Nodal, hypoxia-inducible factor-1α, Roundabout-4, Sema4D, Ephrin-A1, Ephrin-B1, Ephrin-B2, EphA2, EphB2, EphB4, fibroblast growth factor 2, fibroblast growth factor receptor 1, CD133, Notch1, Nodal, Dll4, sonic hedgehog, Runx-1, ETV2, Mig-7, Twist-related protein 1, TIE1, uPA, TIE2, hepatocyte growth factor, matrix metalloproteinase 2 (MMP2), MMP9, and angiogenin [44, 45]. The gene discussed is NODAL; the disease is cancer.