The serologic stability of MSP1 make it an attractive candidate as a surrogate endpoint of exposure for chemoprophylaxis trials, but unfortunately, in a proof-of-concept P. falciparum controlled human malaria infection (CHMI) study by Moon et al. [10], antibodies to PfMSP142 were not induced in malaria-naive, healthy volunteers taking mefloquine chemoprophylaxis with strict clinical and parasitologic monitoring; however, it may be possible that assessment MSP142 as a surrogate biomarker in endemic populations may be of more utility. This evidence concerns the gene ATAD1 and malaria.