F5 and migraine disorder: Additionally, based on our studies, it could be speculated that the factor Leiden V mutation found in one family carrying no causative mutations in SCNA1A, CACN1A, KCNK18, or ATP1A2 is a sole cause of migraine with aura and vision disability and strokes in that family, in line with several reports showing a linkage between migraine and Leiden factor variants [27, 28].