SCN1A and migraine disorder: In a female patient with migraine without aura and with onset at puberty, we found a novel intronic polymorphism possibly affecting alternative splicing of SCN1A, at 2:166852491, g.77659T>C, c.4581+32A>G, located between exons 24 and 25, in a region encoding inactivation loop of the channel (Fig. 1b).