To identify the genetic background of migraine in Polish patients, we screened ATP1A2, CACNA1A, SCN1A, and KCNK18 for mutations in a group of 60 patients with migraine without aura or with different types of aura migraine: typical, sporadic hemiplegic and familial hemiplegic or probable familial hemiplegic. This evidence concerns the gene SCN1A and migraine disorder.