LRP1 and migraine disorder: Moreover, recent genome-wide association studies (GWAS) have identified four novel genetic variants associated with migraine [9]: rs1835740 modulating glutamate homeostasis and specific for migraine with aura; rs11172113 implicating lipoprotein receptor LRP1, which may interact with neuronal glutamate receptors; rs10166942 in close proximity to TRPM8, encoding a cold and pain sensor; and rs2651899 in PRDM16, with an unclear role [9].