SERPINF1 and neoplasm: Moreover, upon PEDF binding, the PEDF-RN can potentially induce phospholipase A2 liberating fatty acids and lysophosphatidic acid from phospholipids [50–52], which could act as second messengers for signal transduction in neuronal cell development and survival, or possibly trigger anti-tumorigenic (e.g. apoptotic role of fatty acids omega-3 docosahexaenoic acid (DHA) in tumour cells [53].