TRPA1 and osteoarthritis: In the monosodium iodoacetate (MIA)-induced osteoarthritis (OA) model systemic or intra-articular HC-030031 failed to block weight asymmetry and ongoing pain at the 1-hour time point [40], systemic injection of another TRPA1-antagonist, A-967079, reduced the evoked neuronal responses to high-intensity mechanical stimulation, but did not alter their spontaneous firing in osteoarthritic animals [41].