The age-dependent role for TRPA1 in pain behaviour occurring in the adjuvant-induced arthritis model has very recently been revealed: old (>18 months old) TRPA1 KO mice developed significantly lower mechanical hypersensitivity as compared to their wildtypes throughout the 8-week experimental period, while the young (3–6 months old) TRPA1-deficient ones revealed that only during the first 2 weeks [43]. This evidence concerns the gene TRPA1 and Arthritis.