FOXF2 and cleft palate: We found that both Foxf2c/-Wnt1-Cre and Foxf2c/-Osr2IresCre/+ mice have complete penetrance of cleft palate and many of the mutant embryos showed failure of palatal shelf elevation, similar to the cleft palate phenotype in mice with constitutive inactivation of the Foxf2 gene (Foxf2-/-), (Fig 1).