TRPV1 and Paralysis: More recently, several studies have reported that TRPV1 functionally interacts with BoNT⁄A, for example, capsaicin, a TRPV1 agonist, inhibits BoNT⁄A–induced paralysis[23], and BoNT⁄A decreases the expression of meningeal TRPV1 in the context of neuropathic pain [15].