This correlation between elevated PLSCR1 expression and impaired phagocytosis in monocytes and macrophages from SLE patients is consistent with our results showing that knocking-down PLSCR1 expression enhances FcR-mediated phagocytosis in macrophages, whereas overexpressing PLSCR1 inhibits this process. This evidence concerns the gene PLSCR1 and systemic lupus erythematosus.