RUVBL2 and cancer: Rvb1 and Rvb2 (also known as RuvBL1/RuvBL2, Pontin/Reptin, TIP49a/TIP49b) are necessary for cell viability and play essential roles in various complexes involved in fundamental processes such as transcription regulation, DNA damage response and apoptosis (via the chromatin remodelling complexes SWR1, INO80 and TIP60), maturation of small nuclear ribonucleoproteins, cellular development, cancer metastasis and regulation of mitosis [1].