To further explore the direct relationship between c-Myc and hnRNPA1 in gastric cancer cells, siRNA was used to down-regulate the expression of c-Myc in SGC-7901 and BGC-823, the results showed that the down-regulation of c-Myc led to the inhibition of hnRNPA1, furthermore, the expression of PKM2 also significantly decreased (Figure 1H). The gene discussed is HNRNPA1; the disease is gastric cancer.