ERBB3/ERBB4 heterodimers may also be active and relevant for disease relapse in non-small cell lung cancer, where inhibition of ligand-dependent ERBB3/ERBB4 signaling with a NRG1-blocking antibody enhanced the magnitude and duration of response to chemotherapy in various mouse models [62]. The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.