The expression of these genes also correlated with an oligodendrocyte-specific molecular signature identifying proneural type of GBM (Verhaak et al., 2010), and E13.5 OLIG2+ SOX2+ progenitors in brains from Cre+, RestGTi/GTi, Trp53fl/fl mice exhibited DNA damage (Figure 8B). The gene discussed is OLIG2; the disease is glioblastoma.