Premature loss of REST from neural progenitors, coupled with loss of the tumor suppressor p53, leads to invasive GBM. The DNA damage due to loss of REST, in the absence of apoptosis with p53 deletion, persisted into adulthood and led to primarily proneural type GBM with PNET character (Kouyialis et al., 2005; Shingu et al., 2005; Ohba et al., 2008; Song et al., 2011). This evidence concerns the gene REST and glioblastoma.