REST and neoplasm: Previous studies support the idea that REST is a tumor suppressor outside of the nervous system (Wagoner et al., 2010; Baye and Link, 2007; Wagoner et al., 2010; Westbrook et al., 2008; Gurrola-Diaz et al., 2003; Kreisler et al., 2010; Moss et al., 2009), but tumors generally reflect the loss of more than one tumor suppressor.