However, some tumors also expressed markers typical for mesenchymal and neuronal GBM types (Figure 8A, Figure 7—figure supplement 2), reflecting the fact that GBM are very heterogeneous, even when derived from single clones from patients (Yung et al., 1982; Wikstrand et al., 1983) including heterogeneity in REST expression (Wagoner and Roopra, 2012; Kamal et al., 2012; Conti et al., 2012). This evidence concerns the gene REST and glioblastoma.