The most striking example of this was the ABO SNP rs8176746 that determines the B versus A allele which showed a positive malaria-related cline with the B-producing allele in this study but in most case-control studies (supplementary table S2, Supplementary Material online), including that here, is reported to confer slightly higher or equal susceptibility of B carriers relative to A carriers, and considerably higher susceptibility of AB heterozygotes compared with A or B (Fry, Griffiths, et al. 2008; Panda et al. 2011; MalariaGEN 2014). This evidence concerns the gene ABO and malaria.