The second example was the O-determining allele at the ABO locus coded for by SNP rs8176719 which has been very consistently demonstrated to protect against severe malaria relative to non-O alleles (A or B) in multiple case-control studies (Cserti and Dzik 2007; Fry, Griffiths, et al. 2008; Rowe et al. 2009; MalariaGEN 2014) but which showed a negative, albeit nonsignificant environmental correlation with malaria here (r = −0.23, P = 0.35). The gene discussed is ABO; the disease is malaria.