To determine if they directly induce distinct embryonic and intestinal SC programs, we expressed KRASmut, LGR5, and pCCL control lentiviral vectors in SW48 cells, which harbored KRASwt and had LGR5 expression in the lower quartile of human colorectal cancer cells (Figure 2A and 2B). The gene discussed is LGR5; the disease is colorectal cancer.