LGR5 and colon adenoma: The degree of plasticity of the colon adenoma-initiating cell lies not only in the intrinsic stem cell properties of the LGR5+ colon stem cell, but more importantly, is a direct consequence of KRASmut, which induces dedifferentiation by activating the embryonic SC-like program beyond the intrinsic intestinal SC program of the LGR5+ colon stem cell.