Among these three genes, the roles of AMOTL1 and SDPR in cancer cell biology were largely analyzed: AMOTL1 (angiomotin-like 1) and its paralog ANGIOMOTIN (AMOT) suppresses the Hippo pathway by interacting with the YAP and TAZ effectors [11]; the down-regulation of SDPR/CAVIN2 mRNA affects caveola formation in breast cancer cells [12]. The gene discussed is CAVIN2; the disease is breast cancer.