From each dataset, we selected the top 5% of genes that were differentially expressed between breast cancer cells and normal breast epithelium, and then extracted three up-regulated (ATIC, C1orf43, RAG1AP1) and five down-regulated genes (AMOTL1, CRYAB, FAM189A2, SDPR and TSHZ2) shared among the seven datasets (Figure 1A; see Supplementary Figure S1 for details). The gene discussed is ATIC; the disease is breast cancer.