GLI1 and pancreatic ductal adenocarcinoma: And either canonical or non-canonical pathway of Hh signaling somehow enhance the nuclear accumulation and transcriptional activity of GLI1: we reported that oncogenic mutation of K-RAS and the activated downstream MAPK/ERK pathway are involved in the derepression of GLI1 from the negative control of Suppressor-of-Fused (SUFU) to enhance the nuclear accumulation and transcriptional activity of GLI1 in pancreatic ductal adenocarcinoma cells [7].