AKAP12 is regulated by methylation in a number of cancers26, 27, 28, 29, 30, 31, 32, 33 and is epigenetically repressed in MM, where its expression can be upregulated following treatment with DNA demethylation compounds such as trichostatin and/or 5-aza-2′-deoxycytidine34. The gene discussed is AKAP12; the disease is Miyoshi myopathy.