RAI1 and Potocki-Lupski syndrome: The observation that DEAF1 binds to a site within the RAI1 gene and activates RAI1 mRNA expression in vitro suggests that RAI1 may be a downstream effector for DEAF1 and genetic differences in the regulation of RAI1 by DEAF1 may contribute to phenotypic differences observed in SMS and PTLS patients and other common mental disorders.