In our case series, one mother was affected by Sjögren Syndrome, but she was asymptomatic and the diagnosis was performed after NLE identification in her son; the second one suffered from an already known SLE and the third one remained asymptomatic with anti-Ro/SSA; the fourth mother was affected by Sjogren Syndrome. The gene discussed is CALR; the disease is systemic lupus erythematosus.