β-TrCP (beta-transducin repeat-containing protein), the E3 ligase/substrate recognition subunit of the SCF (Skp1-Cullin 1-F-box protein) protein complex, has been shown to mediate PHLPP1 degradation in tumours—as this regulation occurs via the PP2C domain conserved in both PHLPPs38, we tested PHLPP2-β-TrCP association in primary hepatocytes and hepatoma cells. Here, SKP1 is linked to hepatocellular carcinoma.