In a study carried out in recent years in order to understand vesicoureteral reflux mechanisms and structural changes they induce in the urinary system, 32 patients with vesicoureteral reflux at varying degrees were compared with 8 control cases regarding presence of intramural c-kit positivity cell and it was determined that collagen stroma replaced smooth muscle bundles and these was remarkable reduced in interstitial cells. The gene discussed is KIT; the disease is vesicoureteral reflux.