KLK3 and cancer: By contrast, the PSA was significantly lower in those with a normal biopsy vs cancer (median 3.4 vs 5.0, p<0.0001 by Mann-Whitney) driven by high PSA values in those with high grade disease (Gleason score 7 or higher median PSA 5.12, p=0.0002 by Kruskal-Wallis with Dunn Multiple Comparison test).