CD8A and Hepatic fibrosis: The results demonstrated that HCV patients with moderate fibrosis (F1-2) presented high frequency of CD8+ T-cells (Fig. 2a) along with lower levels of proinflammatory cytokines (IL-6 and IFN-γ) but higher IL-10 levels as compared to those patients with severe liver fibrosis (F3-4) (Fig. 2b).