ICAM1 and neoplasm: Firm adhesion of tumor cells with the endothelial cells are mediated by cell adhesion molecules such as the Intercellular Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1) from the immunoglobulin family as well as the integrin family, leading to tumor invasion38, 39.