The potential difference of angiogenic activity between WT and PKN3 KO mice does not seem to cause this difference, because the tumor diameters were overall less than 1 mm at the time point of mouse dissection (14th day after the tumor injection), and the PKN3 KO mice did not show suppression of tumor angiogenesis from our subcutaneous tumor implant experiments (Fig. 5). This evidence concerns the gene PKN3 and neoplasm.