Diabetes-induced aberrant overexpression of miR-320 in cardiac myocytes and further delivery of this miRNA to myocardial ECs by cardiac exosomes results in downregulation of the endothelial production of Hsp20, insulin-like growth factor-1 (IGF-1) and transcription factor Ets2 [40,41]. The gene discussed is IGF1; the disease is diabetes mellitus.