TPBG and non-small cell lung carcinoma: Sapra et al (2013) have developed an ADC combined with a tubulin inhibitor that targets 5T4 oncofetal antigen, which is an antigen expressed in TICs in NSCLC and has been associated with an invasive phenotype. A phase I trial investigating this ADC is currently recruiting patients with NSCLC and other solid tumours (Figure 1).