Plasma COL3A1 of the CRC patients (n = 86), but not enteritis (n = 21) and polyps (n = 3) patients, was significantly higher than that of the healthy donors (n = 68) (unpaired Student's t test, p = 1.3E-10) (Figure 4A). The gene discussed is COL3A1; the disease is colorectal carcinoma.