TIGIT and Autoimmunity: Given our finding, in addition to cART, some EC may benefit from TIGIT blockade to alleviate the persistent T cell immune activation thereby reducing the risk of adverse non-AIDS events that have been documented to occur in this population, however such strategies need to be considered carefully given the risk of autoimmunity as described in anti-PD-1 clinical trials in the oncology field [49,50].