In addition, the mouse model of Schistosoma mansoni infection has helped characterize the role of IL-10 as an anti-inflammatory cytokine required to control liver pathology following egg deposition and, more broadly, has helped define IL-10 immunoregulation in other diseases in which inflammation drives pathology, including ulcerative colitis, Crohn’s disease, and, in the lung, allergy and asthma. This evidence concerns the gene IL10 and ulcerative colitis.