2006) and CHUK proteins modulate NF‐kB activation of several genes involved in insulin resistance (Yuan et al. 2008). For the SNPs rs11597086 and rs2862954, the rate of polymorphism in our sample Bronx population was lower than in the average Puerto Rican population (OR 0.54, P = 0.003; OR 0.54, P = 1.5E‐3). In our study, these variations also occur less frequently in NAFLD cases than would be expected in a random Puerto Rican population (OR 0.61, P = 0.09, OR 0.60, P = 0.07). This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.