Necrotizing retinopathy caused by VZV can present as acute retinal necrosis (ARN) or progressive outer retinal necrosis (PORN) in immunocompetent and immunocompromised patients but PORN occurs almost exclusively in HIV-seropositive patients with CD4 cell count < 100 cells/uL [15]. This evidence concerns the gene CD4 and acute retinal necrosis syndrome.