In addition, PD-linked C92F and W437X mutations which are located outside of the PINK1 kinase domain were recently shown to impair the ability of PINK1 to localize on the OMM of depolarized mitochondria [44], indicating that mutation-induced loss of mitochondrial damage-sensing function of PINK1 is another mechanism that triggers impaired mitochondrial quality control. This evidence concerns the gene PINK1 and Parkinson disease.