A number of PD-linked mutations found in the PINK1 kinase domain, such as PINK1 G309D, L347P, C388R, and G409V mutations, have been shown to abolish the kinase activity of PINK1 for phosphorylating its substrates and the ability of PINK1 to promote parkin recruitment [40, 69, 81, 82], indicating that mutation-induced loss of PINK1 catalytic activity is a mechanism leading to impaired mitophagy and neurodegeneration. The gene discussed is PRKN; the disease is Parkinson disease.