In parkin, PD-linked L283P mutation found in the phospho-Ser65-ubiquitin-binding interface has been shown to impair parkin recruitment and activation on depolarized mitochondria [72–75], indicating that mutation-induced loss of phospho-Ser65-ubiquitin-binding ability of parkin can also lead to impaired mitochondrial quality control and neurodegeneration. Here, PRKN is linked to Parkinson disease.