Furthermore, a number of PD-linked mutations found in the parkin E3 ligase domain, such as parkin T240R and G430D mutations, are able to disrupt the E3 ligase activity of parkin for ubiquitinating its substrates and the ability of parkin to promote mitophagy [35, 50, 68], indicating that mutation-induced loss of parkin catalytic activity is another mechanism that causes impaired mitochondrial quality control and familial PD pathogenesis. The gene discussed is PRKN; the disease is Parkinson disease.