The major response to therapy of children positive to WT1 could be related due to the fact that WT-1 gene is a tumor suppressor gene which interacts with multiple hematopoiesis regulation factors, regulates the transcription and expression of genes, as well as takes part in the proliferation, apoptosis, and differentiation of hematopoietic cells.21,22 Thus Wilms’ tumor-1 protein (WT1) is a transcription factor that can either activate or repress genes to regulate cell growth, apoptosis and differentiation. Here, WT1 is linked to neoplasm.