WT1 and neoplasm: 20 WT-1 gene is a tumor suppressor gene extracted initially from cells of Wilms’ tumor. The gene encodes cysteine-histidine zinc finger, a transcription factor which interacts with multiple hematopoiesis regulation factors, regulates the transcription and expression of genes, as well as takes part in the proliferation, apoptosis, and differentiation of hematopoietic cells.21 As a transcription factors, the product encoded by WT-1 gene can activate or inhibit the proliferation of cells, and expressions of differentiation and regulation genes.22