Genetic studies showed that single nucleotide polymorphisms (SNPs) in the IL28B gene, which encodes interferon (IFN)-λ-3 are associated with spontaneous HCV clearance.8 Among the most significant SNPs were rs12979860 and rs12980275.9–11 The aim of this study is to determine the prevalence of HCV infection and IL28B gene polymorphisms among Egyptian children with SCD and to explore the possible relation between IL28B SNPs (rs12979860 and rs12980275) and spontaneous viral clearance. The gene discussed is IFNL3; the disease is Schnyder corneal dystrophy.