Specifically, the linear growth rate for SMMSE increased by 0.12 log-transformed SMMSE points per unit of time in all participants and by 0.13 in women after adjustment for sociodemographic, lifestyle variables, number of chronic diseases, BMI, and apoE ε4 genotype (Model 3 in Table 2), indicating cognitive decline with time. This evidence concerns the gene APOE and Mental deterioration.