DP1 was associated with a 74% increased risk of cognitive impairment (P = 0.03) compared with DP2 after adjustment for all covariates (Model 4), but it was attenuated by apoE ε4 genotype (1.63; CI: 0.95, 2.79; P = 0.07) (data not shown). This evidence concerns the gene APOE and Cognitive impairment.