In the 3-City cohort study of over 8000 older French (aged ≥65), only apoE ε4 noncarriers benefited from DPs characterized by daily intake of fruits and vegetables, and weekly consumption of fish, and had a 2-fold increased risk of AD if the consumption of n–6 PUFA rich-oils was not counteracted by n–3 PUFA food sources (20). Here, APOE is linked to Alzheimer disease.