The most abundant and significantly upregulated mRNA in the DE genes from HDM lungs (Table 1) were molecules that have been previous shown to be induced in human asthma (Thai et al., 2005; Kulkarni et al., 2010; Louten et al., 2012; Bhakta et al., 2013) such as chloride channel calcium activated member-3 (clca3), eosinophil associated ribonuclease A family 11 (ear11) and mucin-5AC, those associated with allergic diseases (il-13, il-13ra2, il-10 and il-21), and chemokines involved in cellular recruitment to the lungs (ccl11, ccl12 and ccl24). Here, IL21 is linked to allergic disease.