GPBAR1 and metabolic dysfunction-associated steatohepatitis: In addition, secondary BAs activate the membrane G-protein-coupled receptor GPBAR1 (also known as M-BAR, TGR5 or BG37)12, and the exogenous dual control over the two receptors represents an attractive strategy for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes13, 14, 15.