ANGPTL8 and type 2 diabetes mellitus: Betatrophin has been suggested a liver-derived hormone that is capable of inducing β-cell proliferation by Yi et al. [10], and a number of studies showed that betatrophin upregulated in T2DM patients [12, 18, 19], while Gomez-Ambrosi et al. studies showed that circulating betatrophin level was reduced in T2DM patients [15].