The association between the distribution of serum bicarbonate and the odds of RHF, defined as an eGFR with an adjusted residual higher than the 95th percentile, was analyzed with multivariate logistic regression analysis, adjusted for age, sex, smoking status, regular exercise, alcohol ingestion, history of pharmacological therapy for hypertension and/or diabetes, BMI, systolic BP, fasting serum glucose, serum uric acid, serum calcium, serum albumin, serum triglyceride, serum high-density lipoprotein cholesterol, and albuminuria. The gene discussed is ALB; the disease is diabetes mellitus.