PNPLA2 and benign prostatic hyperplasia: Based on these results, we targeted Atgl for RNAi analysis of the JGM-induced molecular influence on the reproduction and biochemistry of BPH because Atgl was upregulated by 3.3 folds in the JGM-treated females compared to that in the control females and because it plays an important role in the energy metabolism pathway required for reproduction (Fig. 1).