The deubiquitinating enzyme (DUB) BRCA-1-associated protein 1 (BAP1) is a critical tumor suppressor that has attracted medical interest in the past years since its loss leads to a variety of cancers1 including metastatic cutaneous and uveal melanoma, pleural mesothelioma, renal cell carcinoma and bladder tumours2, 3, 4, 5, 6, 7, 8. The gene discussed is BAP1; the disease is neoplasm.