MAPT and Alzheimer disease: In view of the fact that Tau-aggregation can be present in locus coeruleus (LC) and entorhinal cortex (EC) already early in life, but only spreads from EC to functionally connected brain regions during conversion to MCI and AD—generally hypothesized due to increasing Aβ burden-, we analyzed whether pre-aggregated Aβ could accelerate propagation of incipient Tau-pathology [3, 19, 31].