Prion-like seeding and propagation of Tau-aggregation has been demonstrated to occur between functionally connected brain regions [1, 6, 16, 17, 22, 28, 39, 44, 51], reminiscent of the progression of Tau-pathology in AD [1, 3, 7, 22, 27, 51]. This evidence concerns the gene MAPT and Alzheimer disease.