TARDBP and neurodegenerative disease: In neurodegenerative diseases, recent studies have revealed that several disease-related proteins (TAR DNA-binding protein of 43 kDa (TDP-43), fused in sarcoma (FUS), ataxin-2, survival of motor neuron (SMN) and so on) can associate with SGs, and that SG marker proteins colocalize with pathological inclusion bodies in the patients' brain tissues47, 48, 49.