TP53 and cancer: The Cancer Genome Atlas Network researchers investigated somatic copy number alterations in 257 tumors and identified potential targets of arm-level changes, including gains of 1q, 7p, 7q, 8p, 8q, 12q, 13q, 19q, 20p, and 20q, and losses of 1p, 4q, 5q, 8p, 14q, 15q, 18p and q including SMAD4 (in 66% of the tumors), 17p and q including TP53 (in 56% of the tumors), 20p, and 22q.