One study found that the level of phosphorylated ERK-1/2 was selectively decreased in LRP1-silenced cancer cells, whereas the level of phosphorylated JNK-1/2/3 was increased in cells, suggesting that LRP1 may serve as an intracellular signaling regulator by regulating the ERK and JNK signaling pathways [17]. This evidence concerns the gene MAPK8 and cancer.