LRP1 and breast cancer: For example, Benes et al. [18] observed polymorphic alleles of C766T in exon 3 of LRP1 gene and a marked increase in the frequency of the LRP1 T allele in patients with breast cancer compared with control populations (0.21 versus 0.15, P = 0.01963), suggesting that the T allele of C766T in the LRP1 gene may increase the risk of breast cancer.