Recent research has demonstrated that many metabolic diseases were associated with altered serum irisin level12, irisin is considered to mediate the benefits of exercise in these metabolic disorders13, including diabetes, obesity, and other related metabolic disorders by promoting the browning of beige fat cells in white adipose tissue, which results in enhanced thermogenesis and increased energy expenditure14, 15. This evidence concerns the gene FNDC5 and obesity due to melanocortin 4 receptor deficiency.