TARDBP and early-onset autosomal dominant Alzheimer disease: Additionally, TDP-43 immunoreactive inclusions have also been observed in an increasing spectrum of other neurodegenerative disorders, which include ALS/parkinsonism–dementia complex of Guam, Alzheimer disease (AD), dementia with Lewy bodies (DLB), Pick’s disease, argyrophilic grain disease and corticobasal degeneration (reviewed in 5,12).