The SMARCA4 module (Figure 5A) includes 11 genes: FGFR3, RPL8, EEF1D, CTBP1, MYC, PARP10, ACTL6A, SMARCA4, CCNE1, HSF1, and DNAJB1. FGFR3 genetic alterations frequently occur in myeloma and bladder cancers, suggesting that this molecule plays a vital role in carcinogenesis [21]. This evidence concerns the gene ACTL6A and plasma cell myeloma.