They collected study population from patientsreferred to Shahid Rajaei Cardiovascular Medical and Research Center, Tehran,Iran[33].Despite the adverse effect of ACE DD genotype on hypertension in type 2 diabeticpopulation reported by Nakhjavani et al.[34], Nikzamir et al.[35] found no relation between ACE I/Dpolymorphism and the presence of metabolic syndrome in patients with type 2diabetes. This evidence concerns the gene ACE and hypertensive disorder.