WNT1 and central nervous system cancer: In particular, Notch signaling promotes the formation of cancer stem cells in human glioma [20] and inhibition of Notch signaling reduces primary tumor side population in breast cancer stem cells [42]; similarly, activation of Wnt1 signaling accelerates the proliferation rate and spheroids formation of gastric CSCs [43], while silencing of β-catenin by small interfering RNA could synergize the inhibition of self-renewal of LCSCs induced by BrMC [44].