CSPG4 and neoplasm: Since tumor vessels - in contrast to normal vessels - show a leaky and permeable endothelial cell lining [16–19] which allows for extravasation of larger molecules into the tissue [20, 21] and because NG2 is expressed on pericytes on the abluminal surface of endothelial cells, we hypothesized the presence of a second barrier for selectivity leading to angiogenic tumor vessel infarction induced by tTF-TAA.